Can ‘extrafine’ dry powder aerosols improve lung deposition?
نویسندگان
چکیده
منابع مشابه
Numerical simulation of in-vitro dispersion and deposition of nanoparticles in dry-powder-inhaler aerosols.
Aerosol dispersion and deposition inside an idealized mouth-throat has been numerically simulated using a stochastic Lagrangian model accounting for Brownian motion and particle-wall interaction. Delivery of nanoparticles to the lungs is extremely difficult, mainly due to their low inertia, and for this reason they are often loaded into larger carrier particles. Bearing in mind the potentialiti...
متن کاملBudesonide nanoparticle agglomerates as dry powder aerosols with rapid dissolution.
Nanoparticle technology represents an attractive approach for formulating poorly water-soluble pulmonary medicines. Unfortunately, nanoparticle suspensions used in nebulizers or metered dose inhalers often suffer from physical instability in the form of uncontrolled agglomeration or Ostwald ripening. In addition, processing such suspensions into dry powders can yield broad particle size distrib...
متن کاملScintigraphic comparison of budesonide deposition from two dry powder inhalers.
Chlorofluorocarbons (CFCs), used in metered dose inhalers (MDIs), have been identified as being deleterious to the environment leading to a ban on their production. Dry powder inhalers (DPIs) are a widely used alternative to MDIs. One disadvantage of DPIs is that in vivo lung deposition can be influenced by the patient's inspiratory flow rate. The ASTA Medica multi-dose dry powder inhaler (AM-M...
متن کاملAssessing dry powder inhalers
To enable what would otherwise be impractical, invasive and potentially dangerous testing, and to remove the huge variation and costs associated with human subjects, it is common practice to test inhalation devices and formulations using in vitro test apparatus. Industry standard test conditions and relevant parameters have been devised and published by the regulatory authorities and within the...
متن کاملComparison of Albuterol Sulphate and Base Dry Powder Particulate Deposition Using the Calu-3 Lung Epithelial Model
To effectively predict the fate of formulated inhalation compounds delivered to the lung, a model of the airway epithelium should reflect drug permeability and transport characteristics in vivo. Most cell-based system established for this purpose, study drug transport using wet models and thus do not necessarily represent in vivo conditions. Recently, air-interface models have been established ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Journal of Pharmaceutics and Biopharmaceutics
سال: 2015
ISSN: 0939-6411
DOI: 10.1016/j.ejpb.2015.07.016